Stereoselective Conversion of Anhydrovinblastine into Vinblastine Utilizing an Anti-vinblastine Monoclonal Antibody as a Chiral Mould

Dimeric indole alkaloid, anhydrovinblastine, which can be obtained from catharanthine and vindoline in a high yield, was converted stereoselectively into vinblastine through alternating oxidation-reduction with oxygen and NaBH3CN in the presence of anti-vinblastine monoclonal antibody.

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Bibliographic Details
Published inChemical & Pharmaceutical Bulletin Vol. 54; no. 5; pp. 665 - 668
Main Authors Tatsuya SHIRAHAMAa, Takeyuki KOHNOc, Tomohiro KAIJIMAa, Yasuo NAGAOKAa, b, Daisuke MORIMOTOa, Kazumasa HIRATAd, Shinichi UESATOa
Format Journal Article
LanguageJapanese
Published Pharmaceutical Society of Japan 2006
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Summary:Dimeric indole alkaloid, anhydrovinblastine, which can be obtained from catharanthine and vindoline in a high yield, was converted stereoselectively into vinblastine through alternating oxidation-reduction with oxygen and NaBH3CN in the presence of anti-vinblastine monoclonal antibody.
ISSN:0009-2363
1347-5223