Effects of Immunomodulatory Derivatives of Thalidomide (IMiDs) and Their Analogs on Cell-Differentiation, Cyclooxygenase Activity and Angiogenesis

Various analogs of known immunomodulatory derivatives of thalidomide (1) (IMiDs: 3,5) were synthesized, focusing on cell-differentiation-inducing, cyclooxygenase-inhibitory and anti-angiogenesis activities. Among the prepared compounds, NIDO-33 (14) showed cell differentiation-inducing activity on H...

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Published inChemical & Pharmaceutical Bulletin Vol. 54; no. 6; pp. 855 - 860
Main Authors Haruka FUJIMOTO, Tomomi NOGUCHI, Hisayoshi KOBAYASHI, Hiroyuki MIYACHI, Yuichi HASHIMOTO
Format Journal Article
LanguageJapanese
Published Pharmaceutical Society of Japan 2006
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Summary:Various analogs of known immunomodulatory derivatives of thalidomide (1) (IMiDs: 3,5) were synthesized, focusing on cell-differentiation-inducing, cyclooxygenase-inhibitory and anti-angiogenesis activities. Among the prepared compounds, NIDO-33 (14) showed cell differentiation-inducing activity on HL-60 cells and anti-angiogenic activity on human umbilical vein endothelial cells (HUVEC). AIDO-00 (7) also showed anti-angiogenic activity. NIDO-11 (8) showed an enhancing effect on all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation, and AIDO-30 (13) exhibited cyclooxygenase (COX)-inhibitory activity.
ISSN:0009-2363