Evaluation of the cytocompatibility of methacrylate resin-based root canal sealers with osteoblast-like cells

This study compared the cytocompatibilities of three methacrylate resin-based root canal sealers [MetaSEAL Soft (MSS), Hybrid Root SEAL (HRS), and Superbond Sealer (SBS)] in either freshly mixed or set conditions using the Kusa A1 osteoblastic cell line. The three sealers and an epoxy resin-based se...

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Bibliographic Details
Published inDental Materials Journal Vol. 40; no. 4; pp. 942 - 948
Main Authors Yadanar Su PHYO, Kentaro HASHIMOTO, Nobuyuki KAWASHIMA, Masashi KURAMOTO, Takashi OKIJI
Format Journal Article
LanguageJapanese
Published Japanese Society for Dental Materials and Devices 25.07.2021
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Summary:This study compared the cytocompatibilities of three methacrylate resin-based root canal sealers [MetaSEAL Soft (MSS), Hybrid Root SEAL (HRS), and Superbond Sealer (SBS)] in either freshly mixed or set conditions using the Kusa A1 osteoblastic cell line. The three sealers and an epoxy resin-based sealer (AH Plus; AHP) were extracted in culture medium; cell growth and osteogenic properties were analyzed. Cell adhesion on set sealers was analyzed with scanning electron microscopy. The respective extents of cell growth were as follows in freshly mixed and set sealer extracts: SBS>MSS>AHP>HRS and SBS=AHP>MSS>HRS. Light irradiation of MSS and HRS increased the cell growth of set sealer extracts. Set SBS, MSS, and AHP did not alter expression of osteogenic genes or formation of mineralized nodules. Attached cells were observed only on SBS. In conclusion, the four sealers exhibited varying degrees of compatibility to osteoblasts; SBS and HRS were the most and least compatible, respectively.
ISSN:0287-4547
1881-1361