Guillain-Barré syndrome following hepatitis E

Guillain-Barré syndrome (GBS) is often triggered by a preceding bacterial or viral infection. Occasionally, it has been observed in association with acute hepatitis A, B and C, and three cases have been previously described in India in which GBS was associated with acute hepatitis E. A molecular mim...

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Published inWorld journal of gastroenterology : WJG Vol. 15; no. 13; pp. 1645 - 1647
Main Authors Loly, Jean Philippe, Rikir, Estelle, Seivert, Maxime, Legros, Emile, Defrance, Pierre, Belaiche, Jacques, Moonen, Gustave, Delwaide, Jean
Format Journal Article Web Resource
LanguageEnglish
Published United States Department of Hepato-Gastroenterology, CHU Sart Tilman, Université de Liége, 4000 Liége, Belgium%Department of Neurology,CHU Sart Tilman, Université de Liége, 4000 Liége, Belgium%General Practitioner, rue Neuve, 144, 4860 Pepinster, Verviers, Belgium%Department of Hepato-Gastroenterology, CHPLT La Tourelle, 4800 Verviers, Belgium 07.04.2009
W J G Press
The WJG Press and Baishideng
Subjects
Aged
Autoantibodies - immunology
Case Report
G(M2) Ganglioside - immunology
Gangliosides
Gastroenterology & hepatology
Gastroentérologie & hépatologie
Guillain-Barre Syndrome - etiology
Guillain-Barre Syndrome - immunology
Guillain-Barré syndrome
Hepatitis E
Hepatitis E - complications
Hepatitis E - immunology
Human health sciences
Humans
Male
Molecular Mimicry
Sciences de la santé humaine
Viral hepatitis
Hepatitis E
Viral hepatitis
Molecular mimicry
Gangliosides
Guillain-Barré syndrome
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Summary:Guillain-Barré syndrome (GBS) is often triggered by a preceding bacterial or viral infection. Occasionally, it has been observed in association with acute hepatitis A, B and C, and three cases have been previously described in India in which GBS was associated with acute hepatitis E. A molecular mimicry mechanism is supposed to be involved in the pathogenesis of GBS triggered by infectious agents, although the nature of the shared epitopes has not been characterized in most instances, including that in the case of hepatotropic viruses. We report a case of GBS following acute hepatitis E in a European individual. The presence of antiganglioside GM2 antibodies in this patient suggested molecular mimicry involving ganglioside GM2 in the pathogenesis of GBS associated with hepatitis E.
Bibliography:scopus-id:2-s2.0-64549157533
Telephone: +32-4-3667256
Correspondence to: Jean Delwaide, Department of Hepato-Gastroenterology, CHU Sart Tilman, Université de Liège, 4000 Liège, Belgium. jean.delwaide@chu.ulg.ac.be
Fax: +32-4-3667889
Author contributions: Loly JP, Rikir E, Seivert M, Moonen G, Delwaide J wrote the manuscript; Legros E and Defrance P provided the relevant clinical data; Belaiche J contributed to the discussion and reviewed the manuscript.
ISSN:1007-9327
2219-2840
2219-2840
DOI:10.3748/wjg.15.1645