자율신경균형 증진 간호중재를 위한 생행동적 이론적 기틀 구축: 세포노화 기전 기반으로

• Published in: Journal of Korean biological nursing science Vol. 26; no. 2; pp. 99 - 110
• Main Authors: Nahyun Kim, Jooyeon Park
• Format: Journal Article
• Language: Korean
• Published: 한국기초간호학회 31.05.2024
• Subjects: 간호학; Psychological stress; 자율신경계; theoretical; Autonomic nervous system; 세포노화; Cellular senescence; Models; 심리적 스트레스; 이론적 기틀
• ISSN: 2383-6415; 2383-6423
• DOI: 10.7586/jkbns.24.008

Purpose: This study reviewed the pathophysiological mechanisms of cellular aging caused by psychological stress and aimed to establish a biobehavioral theoretical framework for nursing interventions to promote autonomic balance based on these mechanisms. Methods: A comprehensive literature review was conducted. Results: A review of the literature showed that the stress response increases the secretion of catecholamines and glucocorticoids, resulting in a greater allostatic load. This load induces inflammatory reactions and oxidative stress, shortening telomere length and damaging mitochondrial DNA, which can lead to cellular aging. Based on this mechanism, a biobehavioral theoretical framework for nursing interventions was established. This framework focuses on delaying or inhibiting the cellular aging process by acting on the stress response stage and improving autonomic balance. Conclusion: According to the proposed biobehavioral theoretical framework, stress-relieving nursing interventions may act on the mechanism of cellular aging caused by stress responses. We believe that this framework could expand our understanding of the biobehavioral aspects of stress and would facilitate efforts to use biomarkers to evaluate the effectiveness of stress-related nursing interventions at the cellular level.