갑상샘 스캔 정량분석을 통한 갑상샘 섭취율 동시계측법 연구

• Published in: 방사선기술과학 Vol. 46; no. 5; pp. 401 - 408
• Main Authors: 김정수, 김근우
• Format: Journal Article
• Language: Korean
• Published: 대한방사선과학회(구 대한방사선기술학회) 31.10.2023; KOREAN SOCIETY OF RADIOLOGICAL TECHNOLOGY; 대한방사선과학회
• Subjects: 방사선과학; 갑상샘섭취율; 관심영역; 정량분석; Quantitative Analysis; Thyroid Scan; Thyroid Uptake; Region of Interest; 갑상샘스캔; 99mTcO4
• ISSN: 2288-3509; 2384-1168

Thyroid uptake measurements can be subject to measurement errors due to the scoping and positioning of the thyroid gland. To compensate for these limitations, the clinical utility of the thyroid simultaneous counting method as an alternative to thyroid uptake measurement was analyzed and evaluated experimentally through quantitative analysis of images acquired after thyroid scanning. Experimental data were obtained using a Gamma camera (GE infinia), a thyroid uptake system (KOROID 1), and a thyroid neck phantom. Based on the thyroid uptake rate of 1-5% according to the protocol of thyroid scan test (99mTcO4 - , 370 MBq) in normal results, 99mTcO4 - was set in the range of 3.7-18.5 MBq (Matrix: 256×256, Scan time: 1 min, collimator: pin hole, phantom-collimator distances: 7 cm). The acquired images were corrected for the attenuation of isotopes due to the set-up time and half-life by applying the Auto Region of interest (ROI) drawing system, and the significance of the experimental results was evaluated by Multiple linear regression analysis (SPSS, ver. 22, IBM). The thyroid uptake rate showed a significant correlation between the dose and the measured counts when using the thyroid uptake system equipment. Meanwhile, the quantitative analysis counts of phantom images using Gamma camera also showed a significant correlation. Thus confirmed that the correlation between these two experiments was statistically significant (P<0.05). The simultaneous counting protocol, which indirectly measures thyroid uptake from thyroid scans, is likely to be clinically relevant if complemented by additional studies with different variables in patients with thyroid disease.