관심 영역 설정에 따른 Gates법 토리여과율의 유효성 평가

• Published in: 방사선기술과학 Vol. 46; no. 5; pp. 417 - 425
• Main Authors: 박수영, 안성민
• Format: Journal Article
• Language: Korean
• Published: 대한방사선과학회(구 대한방사선기술학회) 31.10.2023; KOREAN SOCIETY OF RADIOLOGICAL TECHNOLOGY; 대한방사선과학회
• Subjects: 방사선과학; 다중채혈 이중 지수 법; Gamma Camera; Multiple Blood Sampling-Dual Exponential Method (MBSDE); Glomerular Filtration Rate (GFR); Gates Method; Region Of Interest (ROI); 관심 영역; 감마카메라; 토리여과율; Gates 법; Gates
• ISSN: 2288-3509; 2384-1168

The glomerular filtration rate (GFR) has been the subject of much research as a key indicator for diagnosing, treating, and monitoring kidney function. The gamma camera method (Gates method) is simple and allows simultaneous acquisition of GFR and renal scintigraphy for each kidney, however its accuracy is inferior. This study aimed to investigate changes in GFR depending on how region of interest (ROI) are set up, which is one of many factors influencing accuracy. GFR was calculated by setting the ROI for each phase of the image acquisition time (Gates-1: 0~1 minutes, Gates-2: 1~3 minutes, Gates-3: 3~27 minutes), and statistical significance was verified based on probability value 0.05 through ANOVA analysis. While there was no statistically significant difference among results from Gates-1, 2, 3 (p=0.481>0.05), overall results from the Gates method tended to overestimate compared to those from the multiple blood sampling-dual exponential (MBSDE) method. When comparing averages between phases, results from Gates-2 were most similar to those from the MBSDE method. Moreover, paired t-test p-values between MBSDE method and phases were as follows Gates-1: 0.021 (p<0.05), Gates-2: 0.280 (p>0.05), and Gates-3: 0.164 (p>0.05) indicating that only Gates-1 had statistically significant differences compared with MBSDE method. Thus, setting ROI around 2~3 minutes is calculated can aid in accurately determining GFR when Gates Method.