Effects of Saururus chinensis BAILL Extract in Rats with Experimentally Chronic Constipation: An application of Clinical Pathology and Digital Image Processing

• Published in: Journal of experimental & biomedical sciences Vol. 25; no. 4; pp. 339 - 347
• Main Authors: Cho, Min-Seok, Choi, Seokyoun, Lee, Gilhyun, Ju, Mi Ha, Choi, Seok-Cheol
• Format: Journal Article
• Language: Korean
• Published: 대한의생명과학회 2019
• Subjects: Saururus chinensis (SC); Loperamide; Rat; Constipation; Digital image processing
• ISSN: 1738-3226; 2288-7415

Saururus chinensis (SC) belongs to the dicotyledonous plants, and its roots, leaves and flowers are white, so it is named three hundred and seconds. It is mainly distributed in Korea, China and Japan. In Korea, it is a native plant distributed in Jejudo and Jirisan areas. It has been known to improve blood circulation, anticarcinogenic effects and purge. However, studies of the efficacy on digestive system is few. This study was conducted to evaluate the effects of oral administered-SC extract in loperimide-induced constipation rats. The amount, weight and water content of the stools were measured. The number and type of stools in the large intestines were measured, and the amount of intestinal mucus was analyzed by serological analysis and histologic special staining. The severity of constipation in SC groups was significantly less than that in control group (non-SC rats). Digital Image processing also showed weaker inflammation on the large intestines of SC groups than that of control group (non-SC group). Especially, with increased dose dependent manner of SC extract, the amount and integrity of intestinal mucus increased. These results suggest that SC extract may prevent the symptoms of constipation.