Association of the Genetic Polymorphisms for CD247 Gene and Tuberculosis Case

• Published in: Journal of experimental & biomedical sciences Vol. 26; no. 1; pp. 22 - 27
• Main Authors: Ju, Yeongdon, Kim, Sung-Soo, Lee, Kyung Eun, Park, Sangjung, Jin, Hyunwoo
• Format: Journal Article
• Language: Korean
• Published: 대한의생명과학회 2020
• Subjects: Tuberculosis; CD247; Mycobacterium tuberculosis; Genetic analysis
• ISSN: 1738-3226; 2288-7415

Tuberculosis is airborne disease caused by Mycobacterium tuberculosis (MTB). Host genetic factors of these tuberculosis play an important role in determining individual difference in susceptibility or resistance to infectious diseases including tuberculosis. CD247 is named CD3zeta chain or CD3ζ. CD247 gene is a protein-coding gene involved in phagocytosis and signal transduction of the T cell receptor (TCR). Also, downregulation of the CD3ζ chain has been associated to chronic inflammation. The aim of this study was to research association of the genetic polymorphisms for CD247 gene and tuberculosis. We analyzed association of CD247 and Mycobacterium tuberculosis using 149 imputed single nucleotide polymorphisms (SNPs) with Korean population. And the results of this study show that seven SNPs of CD247 were identified to associate with tuberculosis. The most significant SNP was rs858545 (OR=1.22, CI: 1.05~1.42, P=0.009481). This study suggests that polymorphisms of CD247 may affect the T cell receptor signaling pathway, which may associate the infection of tuberculosis.