난소절제 마우스에서 잔대 추출물의 인지능 개선 효과

• Published in: 東아시아食生活學會誌 Vol. 27; no. 4; pp. 442 - 449
• Main Authors: 장환희(Hwan Hee Jang), 김행란(Haeng Ran Kim), 이영민(Young Min Lee)
• Format: Journal Article
• Language: Korean
• Published: 동아시아식생활학회 2017
• Subjects: 생활과학; cognitive function; Adenophora triphylla var. japonica; ovariectomized mice; passive avoidance; water maze; japonica; Adenophora triphylla var
• ISSN: 1225-6781; 2288-8802
• DOI: 10.17495/easdl.2017.8.27.4.442

Adenophora triphylla var. japonica extract has been reported to have estrogenic activity and beneficial effects in postmenopausal women requiring estrogen replacement therapy. This study investigated the effects of A. triphylla extract on cognitive function in ovariectomized mice. Water extracts from A. triphylla were administrated to ovariectomized mice fed a high fat diet for 6 weeks. The step through latency time in the passive avoidance test was shortened in ovariectomized mice as compared with sham-operated mice. However, administration of A. triphylla extracts had a tendency to prolong the latency time in ovariectomized mice. Moreover, A. triphylla supplementation caused a significant decrease in mean escape latency in the water maze test. These results indicate that A. triphylla could be used to improve estrogen deficiency-related learning and memory impairments in postmenopausal women.