태극삼의 장기투여가 인지기능향상과 기억력증진에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 36; no. 1; pp. 18 - 22
• Main Authors: 이철형(Cheol-Hyeong Lee), 박지혜(Ji Hye Park), 김규일(Kyu Il Kim), 이서울(Seoul Lee)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2022
• Subjects: 한의학; Scopolamine; Morris water maze; Rat; Brain-derived neurotrophic factor (BDNF); Spatial navigation learning; Postsynaptic density protein 95 (PSD95); Exploration; Cognitive function
• ISSN: 1738-7698; 2288-2529; 2283-2529
• DOI: 10.15188/kjopp.2022.02.36.1.18

To investigate effects of cognitive function improvement whether against Taegeuk ginseng on scopolamine-induced memory impairment in rats. All experiments were conducted in three groups: the control group (CTR), the scopolamine 0.4mg/kg (SCP), and the scopolamine (SCP+T) treated with Taegeuk ginseng 100 mg/kg. Taegeuk ginseng 100 mg/kg daily was orally administered for one month and treated with scopolamine was only for 7 consecutive days on the Morris water maze task. 3 weeks after oral administration of Taegeuk ginseng, subjects were performed the Morris water maze test for 8 days and then the open-field exploration test which to assessed for cognitive function improvement. After behavioral testing, subjects were sacrificed and microdissected brains for neurochemical analysis. In the cognitive-behavioral test, long-term administration of Taegeuk ginseng improved spatial navigation learning task compared with the impeded by scopolamine treatment. In neurochemistry, the expression of the synaptic marker PSD95 (postsynaptic density protein 95) was increased in the hippocampus compared to the scopolamine group. Also, brain-derived neurotrophic factor (BDNF) expression was significantly increased in the taegeuk ginseng administration group. These data suggested that long-term administration of taegeuk ginseng might improve cognitive-behavioral functions on hippocampal related spatial learning memory, and it was correlated with neurotropic and synaptic reinforcement. In conclusion, treatment with taegeuk ginseng may positive outcome on learning and memory deficit disorders.