Replicated Association Study between Tuberculosis and CLCN6, DOK7, HLA-DRA in Korean

Tuberculosis is a global public health problem and manifests itself as a difference in the genetic susceptibility of the host, along with the properties of Mycobacterium tuberculosis (MTB). The single nucleotide polymorphisms (SNPs) and candidate genes proposed in the Genome-wide association study (...

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Bibliographic Details
Published inJournal of experimental & biomedical sciences Vol. 26; no. 3; pp. 238 - 243
Main Authors Kim, Sung-Soo, Park, Min, Park, Sangjung
Format Journal Article
LanguageKorean
Published 대한의생명과학회 2020
Subjects
CLCN6
HLA-DRA
Mycobacterium tuberculosis(MTB)
SNP
DOK7
Mycobacterium tuberculosis (MTB)
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Summary:Tuberculosis is a global public health problem and manifests itself as a difference in the genetic susceptibility of the host, along with the properties of Mycobacterium tuberculosis (MTB). The single nucleotide polymorphisms (SNPs) and candidate genes proposed in the Genome-wide association study (GWAS) on tuberculosis in a recently published Chinese population were reported. In this study, we investigated whether the genetic polymorphism of candidate genes related to tuberculosis is reproduced when targeting Koreans. The CLCN6 (rs12404124, rs198391, rs535107), DOK7 (rs1203104, rs1203103) and HLA-DRA (rs1051336) gene polymorphisms showed statistically significant results. In addition, it was also found whether it acts as an expression quantitative trait loci (eQTL) that can influence gene expression. This study confirmed that the genetic polymorphism of the three genes (CLCN6, DOK7, HLA-DRA) affects the development of tuberculosis and will help to understand the genetic specificity of tuberculosis and the interaction between pathogens and hosts.
Bibliography:KISTI1.1003/JNL.JAKO202029565518761
ISSN:1738-3226
2288-7415