한방 기능성 입욕제 SP1과 SP2의 항산화, 항노화, 미백효과에 관한 연구

• Published in: 동의생리병리학회지 Vol. 24; no. 5; pp. 837 - 842
• Main Authors: 정보경(Bo Kyoung Jung), 박소정(So Jung Park), 김정수(Jung Soo Kim), 한승헌(Seung Heon Han), 손경우(Kyung Woo Sohn), 윤미영(Mi Young Yoon), 이선경(Sun Kyung Lee), 이상재(Sang Jae Lee), 김병주(Byung Joo Kim), 권영규(Young Kyu Kwon), 채한(Han Chae)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2010
• Subjects: 한의학; whitening; Sancheong; bathing aids; anti-wrinkle; antioxidation; traditional Korean Medicinal herb
• ISSN: 1738-7698; 2288-2529; 2283-2529

The purpose of this study is to develop bathing aids as a strategic products to promote the medical tourism in Sancheong Jirisan Oriental medicinal herbs special district using medicinal herbs produced in Sancheong province, and to verify the effect of the bathing aids in vitro. We investigated the cytotoxicity activity, antioxidant activity, antiaging and whitening effects of Sanchung-PNU 1 (SP1) and Sanchung-PNU 2 (SP2) made with traditional medicinal herbs. The cytotoxicity activity was measured by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. Antioxidant activities were determined by DPPH (1.1-diphenyl-2-picrylhydrazyl) radical scavenging capacity assay. We measured the inhibitory effect against tyrosinase activity to prove the whitening effect, and the inhibitory effect against elastase activity to prove the anti-aging effect. Two proposed prescriptions, SP1 and SP2, showed not significant cytotoxicity but significant (p<0.001) improvement in anti-oxidation, anti-wrinkle, and whitening effects compared to the control group. The result shows that these bathing aids have excellent DPPH radical scavenging effect and significant inhibitory effect against elastase and tyrosinase activity. These findings suggest that these bathing aids have a strong antioxidant, anti-aging, and whitening effect.