4종 한약 처방이 db/db 마우스의 혈당 개선에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 18; no. 1; pp. 58 - 62
• Main Authors: 장문석(Mun Seog Chang), 진현선(Hyun Sun Jin), 정계진(Kye Jin Jung), 박선민(Sun Min Park), 최수봉(Soo Bong Choi), 고병섭(Byoung Seob Ko), 박성규(Seong Kyu Park)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2004
• Subjects: 한의학; Type 2 diabetes; Okchun-san (OCS); Body weight change; db/db mice; Anti-hyperglycemia
• ISSN: 1738-7698; 2288-2529; 2283-2529

The effects of herbal medicine on type 2 diabetic animal model were investigated. Herbal medicine were composed with the addition of Coicis Semen into Okchun-san (OCS). Commelinae Herba into Gangsim-tang (GST). Scrophulariae Radix into Hyunsamsunki-san (HSK). and Erythrinae Cortex into Yukmijihuang-hwan (YMH). We evaluated anti-hyperglycemic and body weight reduction activity in diabetic db/db mice. The experimental animals were divided into six groups. as control group and five sample groups. Each 200mg/kg/day of OCS, GST, HSK and YMH was administered with orally for 14days long. 5mg/kg/day of acarbose was administered with orally for 14days long. On day 14, OCS-treated db/db mice had significantly lower fasting blood glucose levels compared to control group(296±25.9 versus 593±16.4mg/dl. p<0.001). During the 2 h intraperitoneal glucose tolerance test (IPGTT), all the sample groups were improved compared to control group but insignificantly. After 14days of extract treatment. body weight in control. YMH and acarbose groups were increased. but OCS. GST and HSK groups reduced. However. it did not significantly lower hemoglobin Alc(HbAlc) in blood of db/db mice. These result suggest that OCS could be effective on insulin-independent type 2 diabetes.