상표초, 백모근, 금앵자 추출물이 2K1C 고혈압 백서의 혈압에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 30; no. 2; pp. 95 - 100
• Main Authors: 김혜윰(Hye Yoom Kim), 안유미(You Mee Ahn), 고민철(Min Chul Kho), 박지훈(Ji Hun Park), 이재윤(Jae Yun Lee), 이수호(Soo Ho Lee), 박승혁(Sueng Hyuk Park), 김병숙(Byung Sook Kim), 강대길(Dae Gill Kang), 이윤정(Yun Jung Lee)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2016
• Subjects: 한의학; 2-kidney and 1-clip; Rosa laevigata; Renin-angiotensin-aldosterone syste; Imperata cylindrica; Nitric oxide; Renovascular hypertension; Mantidis ootheca
• ISSN: 1738-7698; 2288-2529; 2283-2529
• DOI: 10.15188/kjopp.2016.04.30.2.95

The aim of the present study is to investigate the hypotensive effect of Mantidis ootheca (WMO), Rosa laevigata (WIC), and Imperata cylindrica (WRL) in renovascular hypertension rats. Experimental hypertension model is 2-kidney and 1-clip (2K1C) induced rats. 2K1C rats were treated with WMO, WIC, and WRL at dose of 100 mg/kg/day orally for 3 weeks, respectively. Treatment groups with WMO, WIC, and WRL significantly lowered blood pressure. Interestingly, WMO, WIC, and WRL ameliorated endothelium-dependent and independent vascular relaxation in the phenylephrine-precontracted thoracic aorta in hypertension models. In addition, 2K1C-induced hypertension model increased plasma renin activity, however, WMO, WIC, and WRL attenuated those activities. These results suggest that WMO, WIC, and WRL ameliorates vascular dysfunction in 2K1C-induced hypertension models via the regulation of nitric oxide and renin-angiotensin-aldosterone system.