고지방식이 유발 제2형 당뇨모델 마우스에서 작약의 혈당강하 효능

• Published in: 생약학회지 Vol. 45; no. 3; pp. 194 - 199
• Main Authors: 윤구(Goo Yoon), 김수남(Su Nam Kim), 천승훈(Seung Hoon Cheon), 강복윤(Bok Yun Kang), 심정현(Jung Hyun Shim), 조승식(Seung Sik Cho), 임현진(Hyun Jin Lim), 김현정(Hyun Jung Kim), 정유정(Yujung Jung), 윤인수(In Soo Yoon)
• Format: Journal Article
• Language: Korean
• Published: 한국생약학회 2014
• Subjects: 약학; Protein tyrosine phosphatase 1B; Hypoglycemic; Paeonia lactiflora; Peroxisome proliferator-activated receptors
• ISSN: 0253-3073; 2288-9299

The roots of Paeonia lactiflora (PL) has been traditionally used as analgesic, spasmolytic and tonic in Korea, China, and Japan. As part of a search for herbal medicine to treat diabetes and obesity, we confirmed hypoglycemic effect of PL through high fat diet-induced obese and diabetic mice experiments in vivo. Treatment of ethanolic extract from PL led to a significant decrease in glucose level, which is comparable to that of an antidiabetic drug metformin. In addition, PL selectively stimulates the transcriptional activities of both peroxisome proliferator-activated receptor $(PPAR){\alpha}$ and ${\gamma}$, and inhibits enzymatic activity of protein tyrosine phosphatase 1B (PTP1B), which are predicted to be therapeutic target in treatment of type2 diabetes and obesity. Especially, the n-hexane fraction (Hx) from PL ethanol extract showed more potent activities on $PPAR{\alpha}$ and than others and exihibited moderate inhibitory activity against PTP1B.