양파식초가 뇌혈류 및 안전성에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 26; no. 5; pp. 657 - 664
• Main Authors: 최찬헌(Chan Hun Choi), 김경윤(Kyung Yoon Kim), 정우식(Woo Sik Jeong), 전병관(Byung Guan Jeon), 정재곤(Jae Gon Jung), 정종길(Jong Gil Jung), 이상영(Sang Young Lee), 정현우(Hyun Woo Jeong)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2012
• Subjects: 한의학; cerebral blood flow; red onion(Allium cepa L.); onion vinegar; safety examination; GAP-43; red onion(Allium cepa L; )
• ISSN: 1738-7698; 2288-2529; 2283-2529

The aim of this study is to investigate the effects of onion vinegar on the cerebral blood flow by measuring the changes of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) and by observing the recovery of focal ischemic brain injury in rats. Rats are divided into thee groups depending on the medication; control group (no medication), 8.8-OV group (vinegar using 8.8 brix onion medication), 14.6-OV group (vinegar using 14.6 brix onion medication). The medication of onion vinegar significantly increased rCBF but decreased MABP. This result suggests that onion vinegar significantly increased rCBF by dilating arterial diameter. In addition, focal ischemic brain injury is induced in rats by middle cerebral arterial occlusion. The recovery from focal ischemic brain injury is more significantly improved in the groups using onion vinegar compared to the control group. The amount of recovery is measured by the GAP-43 and the medication of onion vinegar significantly increased GAP-43. This result suggests that onion vinegar is effective on the nerve regeneration. After the medication, the change of body weight, outcomes of renal and liver function test, and outcomes of CBC are analysed for safety examination. There are no statistical differences among control group and all experimental groups in the body weight, renal and liver function test, and CBC. In conclusion, these results suggest that onion vinegar can increase rCBF in normal state, and improve the stability of rCBF in ischemic state.