싸리꽃 추출물의 tyrosinase 활성 및 멜라닌합성 억제효과

• Published in: 동의생리병리학회지 Vol. 21; no. 5; pp. 1142 - 1147
• Main Authors: 유인식(In Sik Ryu), 박시준(Si Jun Park), 문연자(Yeun Ja Mun), 고준석(Joon Suk Ko), 신기돈(Ki Don Shin), 이장천(Jang Cheon Lee), 우원홍(Won Hong Woo), 임규상(Kyu Sang Lim)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2007
• Subjects: 한의학; Lespedeza bicolor; tyrosinase ${\alpha}-MSH; melanin
• ISSN: 1738-7698; 2288-2529; 2283-2529

In this study, we investigated the effects of the flowers of Lespedeza bicolor on melanogenesis in a mouse melanocyte cell line, B16/F10 cells. Our results show that the flowers of Lespedeza bicolor significantly inhibits melanin synthesis in concentration-dependent manner. In addition, it was also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. While the flowers of Lespedeza bicolor have no direct inhibitory effect on tyrosinase activity in cell free assay system using mushroom tyrosinase. Moreover, the flowers of Lespedeza bicolor effectively suppressed the ${\alpha}-MSH-stimulated$ melanin formation, tyrosinase activity and dendrite outgrowth. These results suggest that the flowers of Lespedeza bicolor is a potent depigmetation agent.