잔대 추출물의 항염 및 항천식 효과

• Published in: 東아시아食生活學會誌 Vol. 25; no. 5; pp. 813 - 821
• Main Authors: 장환희(Hwan Hee Jang), 김미주(Mi Ju Kim), 조수연(Su Yeon Cho), 김정봉(Jung Bong Kim), 이성현(Sung Hyeon Lee), 이영민(Young Min Lee)
• Format: Journal Article
• Language: Korean
• Published: 동아시아식생활학회 2015
• Subjects: 생활과학; anti-inflammatory; asthma; anti-allergic; Adenophora triphylla
• ISSN: 1225-6781; 2288-8802
• DOI: 10.17495/easdl.2015.10.25.5.813

Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. The purpose of the present study was to evaluate the anti-inflammatory and anti-asthma effects of Adenophora triphylla var. japonica extracts. We investigated the molecular mechanism underlying the effects of 80% ethanol extracts (AE) of A. triphylla on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. AE treatment inhibited pro-inflammatory cytokines such as TNF-${\alpha}$ and IL-6 as well as nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells. In particular, NO and pro-inflammatory cytokine production was suppressed more effectively by aerial parts (AE-A) than roots (AE-R) of A. triphylla. Quantitative RT-PCR assay showed that AE reduced mRNA levels of iNOS and COX-2. We also evaluated the anti-asthmatic effects of AE-A in an ovalbumin (OVA)-induced BALB/c mouse model. AE-A supplementation significantly reduced the amounts of airway eosinophils, IL-4 and IL-13 levels in BALF, and IgE levels in serum as compared with untreated, OVA-induced mice. These results suggest that AE-A can be considered as a therapeutic agent to potentially relieve asthma.