삼백초 추출물이 뼈 파괴세포 분화에 미치는 효과

• Published in: 동의생리병리학회지 Vol. 26; no. 6; pp. 869 - 873
• Main Authors: 김정영(Jung Young Kim), 정종혁(Jungjong Hyuk), 이명수(Myeung Su Lee), 이창훈(Chang Hoon Lee), 김윤경(Yun Kyung Kim), 전병훈(Byung Hoon Jeon), 곽한복(Han Bok Kwak), 김주영(Ju-Young Kim), 최민규(Min-Kyu Choi), 김정중(Jeong Joong Kim), 오재민(Jaemin Oh)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2012
• Subjects: 한의학; osteoclast; RANKL; saururus chinensis
• ISSN: 1738-7698; 2288-2529; 2283-2529

Balance between bone-forming osteoblasts and bone-resorbing osteoclasts is important in bone homeostasis. Unusual balance between bone-forming osteoblasts and bone-resorbing osteoclasts leads to bone diseases, such as osteoporosis. Saururus chinensis has been widely used in oriental medicine. Saururus chinensis has been known that has antioxidant and anticancer effect. But, the effect of Saururus chinensis in osteoclast differentation remains unknown. We examined the effect of Saururus chinensis in receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL)-induced osteoclast differentiation. From the results of our study, we found that saururus chinensis clearly inhibited RANKL-induced osteoclast differentiation in bone marrow macrophages (BMM) in a dose dependent manner without toxicity. Saururus chinensis inhibited the phosphorylation of JNK, P38, AKT, and ERK induced by RANKL. The mRNA expression of NFATc1, TRAP, and OSCAR induced by RANKL was inhibited by Saururus chinensis treatment. Moreover Saururus chinensis suppressed the protein expression of c-Fos and NFATc1 in BMMs treated with RANKL. These results suggest that Saururus chinensis may be a useful drug in the treatment of bone-related disease.