들깨 잎 추출물에서 분리한 Isoegomaketone(IK)의 항 비만 효능

• Published in: 생약학회지 Vol. 46; no. 4; pp. 283 - 288
• Main Authors: 소양강(Yang Kang So), 조윤호(Yun Ho Jo), 남보미(Bo Mi Nam), 이승영(Seung Young Lee), 김진백(Jin Baek Kim), 강시용(Si Yong Kang), 정혜광(Hye Gwang Jeong), 진창현(Chang Hyun Jin)
• Format: Journal Article
• Language: Korean
• Published: 한국생약학회 2015
• Subjects: 약학; 3T3-L1 cells; Anti-obesity; C57BL/6J; Isoegomaketone; High-fat diet
• ISSN: 0253-3073; 2288-9299

In this study, we investigated anti-obesity effect of isoegomaketone (IK) isolated from leaves extract of Perilla frutescens (L.) Britt. cv. We verified differentiation and lipid accumulation by Oil Red O staining in 3T3-L1 cells after IK treatment with differentiation media. IK inhibited mRNA expression of adipocyte specific genes that were related with differentiation of 3T3-L1 cells. We confirmed the effects of IK on body weight and visceral fat mass in obese mice. Mice were randomly divided into three groups; normal diet group (ND), high-fat diet group (HFD) and high-fat diet with IK group (HFD-IK). The obesity mice were induced by feeding the 45% high-fat diet to the C57BL/6J mice during 4 weeks. After HFD-IK was orally administered 10 mg/kg of IK. As a result, the body weight of HFD and HFD-IK was increased 2.4 times and 1.7 times of ND, respectively. Also visceral fat mass of HFD was increased 24 times but in the case of HFD-IK was increased to 13 times in comparison with ND. Taken together, our findings suggest that IK reduced differentiation and adiogenesis in 3T3-L1 cells, decreased the body weight and visceral fat mass in obesity mice. These results suggest that IK may have a potential benefit as anti-obesity material.