목단피에 의한 임신 저해의 분자적 기전에 대한 연구

• Published in: 동의생리병리학회지 Vol. 28; no. 5; pp. 530 - 536
• Main Authors: 최희정(Hee Jung Choi), 김은영(Eun Young Kim), 최희진(Hee Jin Choi), 박미주(Mi Ju Park), 정태욱(Tae Wook Chung), 박성하(Seong Ha Park), 김소연(So Yeon Kim), 하기태(Ki Tae Ha)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2014
• Subjects: 한의학; Contraindicated drugs of pregnancy; LIF; Root barks of Paeonia suffruticosa (牧丹皮); Contraception; LIFR; Root barks of Paeonia suffruticosa
• ISSN: 1738-7698; 2288-2529; 2283-2529
• DOI: 10.15188/kjopp.2014.10.28.5.530

Root barks of Paeonia suffruticosa Andrews (PS) was reported as contraindicated drugs of pregnancy by many Korean medical classics. Recently, a major ingredient component of PS, paeonol was reported that has contraceptive effect on early pregnancy in rats. However, the accurate molecular mechanism is not clear. In this study, we showed that PS decreased the expression of receptor for leukemia inhibitory factor (LIFR) in human endometrial Ishikawa cells at non-toxic dose, although the expression of leukemia inhibitory factor (LIF) was increased by PS. In addition, PS inhibited the adhesion of human trophoblastic JAR cells onto Ishikawa cells. Given importance of LIF-LIFR signaling pathway in the process of embryo implantation, the decreased LIFR expression by PS will be a good explanation on the PS- or its ingredient compounds-induced contraception.