산수유 헥산 추출물의 항균효과 및 세포독성

Cornis fructus was extracted by successive extraction and then fractionated with hexane extract to get active fractions. This study was performed to determine the cytotoxic effect of hexane extract from Cornis fructus on NIH 3T3 fibroblasts and cancer cell lines using MTT assay. Hexane extract showe...

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Bibliographic Details
Published in동의생리병리학회지 Vol. 17; no. 2; pp. 476 - 480
Main Authors 천현자(Hyun Ja Chun), 최원형(Won Hyung Choi), 이정호(Jeong Ho Lee), 양현옥(Hyun Ok Yang), 백승화(Seung Hwa Baek)
Format Journal Article
LanguageKorean
Published 한의병리학회 2003
Subjects
한의학
Corni fructus
Cytotoxic effects
Antimicrobial activities
MTT assay
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Summary:Cornis fructus was extracted by successive extraction and then fractionated with hexane extract to get active fractions. This study was performed to determine the cytotoxic effect of hexane extract from Cornis fructus on NIH 3T3 fibroblasts and cancer cell lines using MTT assay. Hexane extract showed cytotoxic effect against A549, B16 melanoma and MDA-MB-231. Futher fractionation with hexane extract was performed to obtain effective fraction, fraction 3 showed the cytotoxic effect against A549 and MDA-MB-231. In antimicrobial test of each fraction of hexane extract, fraction 5 showed antimicrobial activities against P. putida and P. aeruginosa.
Bibliography:KISTI1.1003/JNL.JAKO200317140942166
G704-000534.2003.17.2.009
ISSN:1738-7698
2288-2529
2283-2529