정제봉독의 아나필락시스 쇼크 반응 연구

• Published in: 생약학회지 Vol. 46; no. 3; pp. 203 - 207
• Main Authors: 한상미(Sang Mi Han), 홍인표(In Phyo Hong), 우순옥(Soon Ok Woo), 김세건(Se Gun Kim), 장혜리(Hye Ri Jang), 박관규(Kyun Kyu Park), 장영채(Young Chae Chang)
• Format: Journal Article
• Language: Korean
• Published: 한국생약학회 2015
• Subjects: 약학; Apis mellifera; Antigenicity; Purified bee venom; Active systemic anaphylaxis
• ISSN: 0253-3073; 2288-9299

This study was performed to examine the antigenic potential of purified bee venom (Apis mellifera L., PBV) collected using bee venom collector. Antigenic potential of PBV was examined by active systemic anaphylaxis (ASA) in guinea pigs. PBV was subcutaneously administered at 0.025 and 0.05 mg/kg and also as a suspension with adjuvant (Freund's complete adjuvant, FCA). Ovalbumin (OVA) as a suspension with adjuvant was used to introduce positive control response. In the weight measurement and clinical observation, experimental groups didn't show any significant changes compared with control group. In the autopsy of body, the abnormalities of lung were detected only in the positive control. In the ASA test, experimental groups didn't show any symptoms of anaphylaxis like piloerection, hyperpnea and staggering gait. These results suggested that PBV didn't have antigenic potential in guinea pig.