녹용 물추출물이 Ovalbumin으로 유도된 천식동물모델에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 19; no. 5; pp. 1243 - 1250
• Main Authors: 박기범(Ki Bum Park), 변성희(Sung Hui Byun), 양재하(Chae Ha Yang), 서정철(Jung-Chul Seo), 변준석(Joon Seok Byun), 김상찬(Sang Chan Kim)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2005
• Subjects: 한의학; Deer Horn; Immunoglobulin; Interleukin; Eosinophil; Asthma
• ISSN: 1738-7698; 2288-2529; 2283-2529

This study was performed to investigate the effect of oral administration of deer horn against the asthma. Deer horn improves body metabolism and strengthens overall health, especially in elderly persons and young children. Additionally, it stimulates sexual function in females and can stimulate wound healing. Asthma was induced to Balblc mouse by i.p. injection and aerosol immunization with ovalbumin. It was observed the change of the eosinophil number in the BALF. Concentrations of IL-4, IL-5 in BALF and splenocyte were assessed by ELISA, IgG and IgE from serum were calculated by same method. The number of eosinophil in BALF was not significantly changed in deer horn group compared with control group. Concentration of IL-4 in BALF was significantly decreased in deer horn group compared with control group. Levels of IL-5 from BALF and splenocyte were significantly decreased in deer horn group compared with control group, respectively. Concentrations of IgE and IgG in serum were significantly decreased in deer horn group compared with control group, separately. We found that the effect of deer horn extract in asthma was implicated in reductions of IL-4, IL-5 released from Th2 cell, and decreases of IgG, IgE from plasma cell. These findings suggest that deer horn extract can produce anti-asthmatic effect, which may play a role in allergen-induced asthma therapy.