4주간 지구성 운동이 흰쥐의 Back Skin Hair Follicle에서 ERK 및 JNK의 활성화에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 20; no. 5; pp. 1211 - 1216
• Main Authors: 김모경(Mo Kyung Kim), 박한수(Han Su Park), 신병철(Byung Cheul Shin), 조성초(Sung Cho Jo), 채정룡(Jeong Ryong Chae), 김모영(Mo Young Kim)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2006
• Subjects: 한의학; Signal transduction; Exercise training; Back skin Hair follicle; JNK; ERK
• ISSN: 1738-7698; 2288-2529; 2283-2529

The effect of a chronic programme of either low- or moderate-to-high-intensity treadmill running on the activation of the Extracellular-signal regulated protein kinase (ERK1/2), Phosphorylated ERK 1/2(pERK1/2) and the Phosphorylated c-Jun N-terminal kinase(pJNK) pathways was determined in rat Back skin Hair follicle. Sprague-Dawley rats were assigned to one of three groups: (i) sedentary group(NE; n=10); (ii) low-intensity exercise group (Bm/min; LIE; n=10); and (iii) moderate-high-intensity exercise group(28m1min; HIE; n=10). The training regimens were planned so that animals covered the same distance and had similar utilization for both LIE and HIE exercise sessions. The report runs as follows; A single bout of LIE or HIE following 4 weeks of exercise led to a twofold increase in the phosphorylation of ERK2, pERK2 and a threefold increase in pJNKl, pERKl. ERKI phosphorylation in LIE Back skin sampled and pJNK2 in HIE Back skin sampled 48h after the last exercise bout was similar to sedentary values, while pJNK2 phosphorylation in LIE Back skin sampled was 70-80% lower than sedentary. 48h after the last exercise bout of LIE or HIE increased ERK2, pERKl and pJNKl expression, with the magnitude of this increase being independent of prior exercise intensity or duration. PERK1/2, pJNKl expression was increased Three- to fourfold in Back skin Hair follicle sampled 48h after the last exercise bout irrespective of the prior exercise programme, but ERKI expression in HIE Back skin sampled was approximately 90% lower than sedentary values. In conclusion, exercise-training of different jntensities/durations results in selective postexercise activation of intracellular signal pathways, which may be one mechanism regulating specific adaptations induced by diverse training programmes.