전침자극과 운동치료가 허혈성 뇌졸중 백서모델의 신경계에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 20; no. 4; pp. 1014 - 1020
• Main Authors: 유영대(Young Dae Yoo), 김기도(Gi Do kim), 천진성(Jin Sung Chun), 김계엽(Gye Yeop Kim), 정현우(Hyun Woo Jeong)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2006
• Subjects: 한의학; HSP70; Electroacupuncture; BDNF; Middle cerebral artery occlusion
• ISSN: 1738-7698; 2288-2529; 2283-2529

This study was intended to examine the effects of electroacupuncture(EA) and therapeutic exercise on the improvement of exercise function, BNDF, and HSP70 protein expression in an ischemic stroke model induced by MCA occlusion. Experiments were conducted for 1, 3 days, 1, 8 weeks respectively. Group I was a group of EA and therapeutic exercise; Group II was a group of therapeutic exercise; Group III was a group of EA; Group IV was a sham group of EA; Group V was a control group; and Group VI was a sham group without ischemic stroke. In each group, neurologic motor behavior test, histologic observations, BDNF, and HSP70 expression were observed and analyzed. The following results were obtained. The results of behavior test suggest that 8 weeks after ischemic stroke was induced, Group I improved in degeneration and inflammation of muscle fiber and decreased in destruction of nerve cells and cerebral infarction, indicating a similar state of muscle fiber and brain to Group VI. In immunohistochemical observations, Group I showed increase in BDNF and decrease in HSP70. Based on these results, EA and therapeutic exercise may improve muscle atrophy and change in BDNF and HSP70 expression of ischemic stroke rats and contribute to the improvement of exercise function.