고과당식이 랫드모델에서 복분자 투여에 의한 대사증후군 개선효과

• Published in: 동의생리병리학회지 Vol. 29; no. 1; pp. 11 - 17
• Main Authors: 고민철(Min Chul Kho), 이윤정(Yun Jung Lee), 윤정주(Jung Joo Yoon), 강대길(Dae Gill Kang), 이호섭(Ho Sub Lee)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2015
• Subjects: 한의학; metabolic syndrome; hyperlipidemia; Rubus coreanus Miq; hypertension; obesity
• ISSN: 1738-7698; 2288-2529; 2283-2529
• DOI: 10.15188/kjopp.2015.02.29.1.11

Overconsumption of fructose results in dyslipidemia, hypertension, which have documented as a risk of cardiovascular diseases. This experimental study was designed to investigate the beneficial effects of Rubus coreanus Miq.(RCM) in high-fructose diet-induced metabolic syndrome. Animals were divided into three groups; Control group fed regular diet and tap water, fructose groups were fed the 65% high-fructose (HF) diet with/without RCM 100 mg/kg/day for 8 weeks, respectively. Chronic treatment with RCM significantly decreased body weight, fat weight and adipocyte size. Moreover, RCM significantly prevented the development of the metabolic disturbances such as hyperlipidemia and hypertension. RCM also led to increase in high density lipoprotein level in the HF group. In addition, RCM suppressed vascular cell adhesion molecule-1 (VCAM-1) expression and significantly recovered the levels of endothelial nitric oxide synthase (eNOS) expression in aorta. These results demonstrates that RCM may be a beneficial therapeutic for metabolic syndrome through the improvement of hyperlipidemia, obesity, and hypertension.