소맥엽의 섭취가 Streptozotocin 유발 당뇨 흰쥐에서 혈중 포도당 및 지질에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 24; no. 6; pp. 1012 - 1018
• Main Authors: 이선희(Sun Hee Lee), 임성원(Sung Won Lim), 이영미(Young Mi Lee), 강천식(Chun Sik Kang), 정연근(Young Keun Cheong), 박철수(Chul Soo Park), 송봉준(Bong Joon Song), 김대기(Dae Ki Kim)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2010
• Subjects: 한의학; plasma lipid; blood glucose; Triticum aestivum sprout; diabetes mellitus; streptozotocin
• ISSN: 1738-7698; 2288-2529; 2283-2529

This study investigated the functional effect by diets of Triticum aestivum sprout (TA) on the levels of blood glucose and lipid profiles in streptozotocin(STZ)-induced diabetic mice. Diabetes mellitus were induced by STZ intraperitoneal injection (50 mg/kg) into the male Balb/c mice. All mice fed AIN-93 diet for 3 weeks. Mice were divided to 4 groups: normal, diabetic control and two experimental groups (TA 5.0, diet with Triticum aestivum sprout 5.0% w/w; TA 2.5, diet with Triticum aestivum 2.5% w/w). The blood glucose level was decreased by TA intake in diabetic mice in the dose-dependant manner; 21.34% and 35.77% in TA 2.5 and TA 5.0 groups. The weight gain and feed efficiency ratio also were improved by TA intake compared with DM group. The weight gain was increased 1.28 and 1.09 folds in TA 5.0 and TA 2.5 groups, respectively. The weight of organs, including liver and kidney, was reduced but that of spleen and abdominal fat was increased by TA intake. Moreover, TA treatment increased the level of HDL but decreased the level of total cholesterol and triglycerides in the blood of diabetic mice. The blood of HbA1c also was significantly decreased without changing hematocrit by TA treatment compared with DM group. These results indicate the TA intake has the functional effects attenuating blood glucose and plasma lipid levels in insulin-dependent diabetes.