왕머루포도 뿌리에서 분리한 heyneanol A의 신경보호효과

• Published in: 동의생리병리학회지 Vol. 21; no. 6; pp. 1411 - 1414
• Main Authors: 황화수(Hwa Soo Hwang), 남궁미애(Mi Ae Namgung), 이은옥(Eun Ok Lee), 심범상(Bum Sang Shim), 안규석(Kyoo Seok Ahn), 김성훈(Sung Hoon Kim)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2007
• Subjects: 한의학; MCAO; edema; resveratrol; infarct; neurological score; heyneanol A
• ISSN: 1738-7698; 2288-2529; 2283-2529

According to the report of Korea National Statistical Office in 2007, cerebral vascular disease is second cause of deaths in Korean. Cerebral ischemia is one of the main reason of cerebral vascular diseases. To evaluate the neuroprotective effect of heyneanol A against cerebral ischemia, we used the middle cerebral artery occlusion model (MCAO). Heyneanol A from root of vitis amurensis Rup is a tetramer of resveratrol as known anti-oxidant and anti-cancer agent. Although the effects of resveratrol in the various fields have been well established, little is known of the effects of heyneanol A. In this study, heyneanol A reduced infarction and edema volume by 33.5% and 57% compared with control groups (vehicle), respectively. Also, neurological score was decreased by heyneanol A. It's effects were more potent than resveratol. Taken together, these results exerted that heyneanol A has a neuroprotective effect against cerebral ischemia.