Protective Effect of HP08-0111 on Ligature-Induced Periodontitis

Periodontitis is an inflammatory disorder of the periodontium and is characterized by destruction of the tooth supporting tissues, mediated by the upregulation of synthesis and release of a variety of pro-inflammatory factors. Inflammatory cytokines and prostaglandins upregulate RANKL and its subseq...

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Bibliographic Details
Published inInternational journal of oral biology Vol. 35; no. 4; pp. 145 - 151
Main Authors Park, Young-Ran, Cho, Hyoung-Kwon, Soh, Yun-Jo
Format Journal Article
LanguageKorean
Published 대한구강생물학회 31.12.2010
Subjects
치의학
anti-inflammatory
osteoclastogenesis
HP08-0111
periodontitis
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Summary:Periodontitis is an inflammatory disorder of the periodontium and is characterized by destruction of the tooth supporting tissues, mediated by the upregulation of synthesis and release of a variety of pro-inflammatory factors. Inflammatory cytokines and prostaglandins upregulate RANKL and its subsequent binding to RANK stimulates osteoclast formation, resorption activity, and survival. In our present study, we investigated the effects of HP08-0111, composed of Coptis japonica (Thunb.) Makino, vitamin C and vitamin E, upon inflammatory responses, osteoclastogenesis and alveolar bone loss. HP08-0111 decreased the expression of IL-1β and COX2 on LPS-induced RAW 264.7 cells and inhibited osteoclast-specific genes such as c-Fos, MMP-9, and TRAP. HP08-0111 also exhibited protective effects against alveolar bone loss in rats with ligature-induced periodontitis. Our results suggest that HP08-0111 is potentially an important therapeutic tool for the treatment of disorders associated with bone loss such as periodontitis.
Bibliography:KISTI1.1003/JNL.JAKO201013351020648
G704-001787.2010.35.4.008
ISSN:1226-7155
2287-6618