월경전증후군에 대한 한약 치료의 효과 : 체계적 문헌 고찰과 메타 분석

• Published in: 大韓韓方婦人科學會誌 Vol. 36; no. 4; pp. 96 - 120
• Main Authors: 서지인, Ji-in Seo, 이윤재, Yun-jae Lee, 고서림, Seo-lim Ko, 김누리, Nu-ree Kim, 김정훈, Jeong-hun Kim, 손미주, Mi-ju Son, 김영은, Young-eun Kim, 김안나, An-na Kim, 이은희, Eun-hee Lee
• Format: Journal Article
• Language: Korean
• Published: 대한한방부인과학회 25.11.2023
• Subjects: Herbal Medicine; Meta Analysis; Premenstrual Syndrome; Randomized Controlled Trials; Systematic Review; 한의학; Meta Analysis; Randomized Controlled Trials; Systematic Review; Herbal Medicine; Premenstrual Syndrome
• ISSN: 1229-4292; 2508-3619
• DOI: 10.15204/jkobgy.2023.36.4.096

Objectives: This study reports the findings that support the efficacy of herbal medicine (HM) for premenstrual syndrome (PMS). Methods: We conducted meta-analysis of findings from randomized controlled trials (RCTs) for PMS treated with HM. The articles were published before July 2022, located using 9 databases (Pubmed, EMBASE, Cochrane Library, CINAHL, CNKI, CiNii, SCIENCE ON, KoreaMed, OASIS). Results: We observed 2,034 studies, of which 23 RCTs met our inclusion criteria. The risk of bias in the included studies was relatively unclear or high. Meta-analysis of 3 RCTs showed that HM group had a significantly higher total effective rate than the western medicine group (RR 1.20 [95% CI 1.06, 1.36, p=0.004]). Meta-analysis of 1 RCT showed that HM group had a significantly lower symptom score (MD -3.04 [95% CI -5.36, -0.72, p=0.01]), while there was no significant difference in daily record of severity of problems scale (MD -20.52 [95% CI -49.33, 8.29, p=0.16]). Conclusions: HM significantly improved PMS symptoms than general treatment and no serious adverse events were reported. However, the evidence on the effectiveness and safety of HM for PMS was not enough to provide reliable results due to the small number and low quality of included studies. We believe that rigorous RCTs will lead to more reliable evidence of the intervention.