Tioacetmaide로 유도된 지질 과산화물 증가 간 독성 Rat 모델에서 맥문동 에탄올 추출물의 간 항산화 효과

• Published in: 大韓本草學會誌 Vol. 40; no. 4; pp. 63 - 72
• Main Authors: 박서인, Park Seo In, 서희원, Seo Hee Won, 오지혜, Oh Ji Hye, 백승화, Beak Seung Hwa, 황석연, Hwang Seock Yeon
• Format: Journal Article
• Language: Korean
• Published: 대한본초학회 31.07.2025
• Subjects: Antioxidant activites; Extract; Liriope platyphylla; Liver; Thioacetamide; 한의학; Thioacetamide; Liriope platyphylla; Extract; Antioxidant activites; Liver
• ISSN: 1229-1765; 2288-7199
• DOI: 10.6116/kjh.2025.40.4.63

Objectives : This study aimed to investigate the hepatoprotective effect of Liriope platyphylla extract (LPE). To achieve this, we quantitatively analyzed the hepatoprotective effects of three different concentrations of LPE in a thioacetamide (TAA)-induced liver toxicity model. Methods : Six-week-old male sprague-dawley (SD) rats weighing 206.4±9.0 g were used in this study. The positive control group was treated with silymarin (SLM) at a concentration of 50 mg/kg, and the experimental groups were treated with LPE at concentrations of 100, 200, and 300 mg/kg. On day 14, all groups except the normal control group were administered TAA at a concentration of 200 mg/kg. Result : As a result, significant reductions in serum levels of liver function enzymes and inflammatory markers (AST, ALT, T-bil, γ-GTP, and LDH) were observed in the LPE-treated groups. Furthermore, LPE administration led to significant, dose-dependent decreases in the activity of the cytoprotective marker cyclooxygenase-2 (COX-2) and the concentration of the lipid peroxidation marker malondialdehyde (MDA) in liver tissue. Concurrently, the activities of antioxidant enzymes, including superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT), were significantly increased. Conclusions : The results of this study suggest that LPE positively affects liver function protection by reducing oxidative stress and increasing antioxidant enzyme activity in liver tissue. Consequently, this study presents the potential for LPE to be developed as a hepatoprotective functional food, based on further research into the mechanisms of its individual components.