급성 약물중독에 합병된 일과성 혹은 지속성 고암모니아혈증의 특성

• Published in: 대한임상독성학회지 Vol. 14; no. 2; pp. 136 - 143
• Main Authors: 이수형, Soo Hyung Lee, 박홍인, Hong In Park, 최마이클승필, Michael Sung Pil Choe, 제동욱, Dong Wook Je, 노우영, Woo Young Nho, 김성훈, Seong Hun Kim, 이미진, Mi Jin Lee, 안재윤, Jae Yun Ahn, 문성배, Sung Bae Moon, 이동언, Dong Eun Lee, 박정배, Jung B
• Format: Journal Article
• Language: Korean
• Published: 대한임상독성학회 30.12.2016
• Subjects: Hyperammonemia; Poison severity score; Poisoning; SOFA; 응급의학; SOFA; Poisoning; Poison severity score; Hyperammonemia
• ISSN: 1738-1320; 2508-6332
• DOI: 10.22537/jksct.2016.14.2.136

Purpose: In patients with altered mentality caused by drugs or unknown causes, ammonia is checked to facilitate differential diagnosis or diagnose hepatic coma. This helps early prevention and treatment of brain damage due to hyperammonemia. This study was conducted to evaluate clinical characteristics of intoxicated adult patients with hyperammonemia. Methods: We evaluated 95 patients with hyperammonemia among intoxicated patients above the age of 15 who visited our ED from January 2013 to December 2015. We analyzed the demographic characteristics and type of poisoning substance, reason for ingestion, toxicological characteristics such as elapsed time from ingestion to hospital visit, lab, clinical progression and complications. Data were evaluated using the student`s t test or Mann-Whitney U test for continuous variables, and Chi-square test and Fisher`s exact test for frequency analysis of categorical variables. Results: When compared to healthy individuals, patients with hyperammonemia showed statistical significance on their SOFA score (p=0.016) and poison severity score (p<0.001). Additionally, patients with hyperammonemia showed significantly different initial serum AST level (p=0.012) and maximum serum AST level during the hospital stay (p=0.026) when compared to healthy individuals. Moreover, individuals with sustained hyperammonemia compared to transient hyperammonemia showed clinically significant SOFA scores (p<0.001), poison severity scores (p=0.007), mortality rates in the ICU (p=0.021), as well as different duration of hospital stay (p=0.037), serum creatinine level (p=0.002), erythrocyte sedimentation rate (p=0.025), and serum myoglobin (p=0.015). Conclusion: Most poisoning-induced hyperammonemia cases were transient and recovered without special treatment. Therefore, hyperammonemia is almost non-specific among poisoning patients.