화합물 합성반응 중 Fridel - Crafts Acylation 공정에서의 폭주반응 위험성평가

• Published in: 한국안전학회지 Vol. 36; no. 3; pp. 24 - 30
• Main Authors: 이광호, Kwangho Lee, 김원성, Wonsung Kim, 전진우, Jinwoo Jun, 주영종, Youngjong Joo, 박교식, Kyoshik Park
• Format: Journal Article
• Language: Korean
• Published: 한국안전학회 30.06.2021
• Subjects: pharmaceutical ingredient; raw material medicine; reaction calorimeter; risk; risk assessment; runaway reaction; 안전공학; raw material medicine; pharmaceutical ingredient; risk assessment; runaway reaction; risk; reaction calorimeter
• ISSN: 1738-3803; 2383-9953

Heat is generated during the synthesis and mixing process of chemical compounds due to a change in activation energy during the reaction. A runaway reaction occurs when sufficient heat is not removed during the heat control process within a reactor, rapidly increasing the temperature, reaction speed, and rate of heat generation inside the reactor. A risk assessment was executed using an RC-1 (Reaction Calorimeter) during Friedel-Crafts acylation. Friedel-Crafts acylation runs the risk of rapid heat generation during Active Pharmaceutical Ingredient (API) manufacturing; it was used to confirm the risk of a runaway reaction at each synthesis stage and during the mixing process. This study used experimental data to develop a safety efficiency improvement plan to control the risks of runaway and other exothermic reactions, which was implemented at the production site of a chemical plant.