심장이식 환자에서 발생한 비결핵항산균 폐질환 2예

• Published in: Tuberculosis and respiratory diseases Vol. 69; no. 3; pp. 201 - 206
• Main Authors: 조정민, Jung Min Jo, 신미선, Mi Seon Shin, 김주희, Joo Hui Kim, 김민정, Min Jung Kim, 박현정, Hyun Jung Park, 나희경, Hee Kyung Na, 조경욱, Kyung Uk Jo, 김재중, Jae Joong Kim, 심태선, Tae Sun Shim
• Format: Journal Article
• Language: Korean
• Published: 대한결핵 및 호흡기학회 30.09.2010; 대한결핵및호흡기학회
• Subjects: Atypical; Heart Transplantation; Lung Diseases; Mycobacteria; 내과학; Heart Transplantation; Mycobacteria, Atypical; Lung Diseases
• ISSN: 1738-3536; 2005-6184

Nontuberculous mycobacterial (NTM) diseases are increasing worldwide. However NTM lung disease in organ transplant recipients has been rarely reported. Here, we report 2 cases of NTM lung disease in heart transplant recipients. A 37-year-old man, who had undergone a heart transplant one year previous, was admitted to hospital due to a cough. Chest CT scan showed multiple centrilobular nodules in both lower lungs. In his sputum, M. abscessus was repeatedly identified by rpoB gene analysis. The patient improved after treatment with clarithromycin, imipenem, and amikacin. An additional patient, a 53-year-old woman who had undergone a heart transplant 4 years prior and who suffered from bronchiectasis, was admitted because of purulent sputum. The patient`s chest CT scan revealed aggravated bronchiectasis; M. intracellulare was isolated repeatedly in her sputum. Treatment was successfully completed with clarithromycin, ethambutol, and ciprofloxacin. NTM lung disease should be considered as a potential opportunistic infection in organ transplant recipients.