건강한 흡연자에서 폐기종의 유무에 따른 폐기능 변화

• Published in: Tuberculosis and respiratory diseases Vol. 69; no. 3; pp. 177 - 183
• Main Authors: 심윤수, Yun Su Sim, 함은재, Eun Jae Ham, 최규용, Kyu Yong Choi, 이숙영, Suk Young Lee, 김석찬, Seok Chan Kim, 김영균, Young Kyoon Kim, 박성학, Sung Hak Park
• Format: Journal Article
• Language: Korean
• Published: 대한결핵 및 호흡기학회 30.09.2010; 대한결핵및호흡기학회
• Subjects: Emphysema; Smoking; Spirometry; Tomography; X-Ray Computed; 내과학; Spirometry; Tomography, X-Ray Computed; Emphysema; Smoking
• ISSN: 1738-3536; 2005-6184

Background: Smoking reduces pulmonary function and induces various lung diseases. Recently, the rate of emphysema detection has increased due to lung cancer screening with low-dose chest computed tomography (CT). The purpose of this study was to evaluate changes in lung function associated with emphysema in healthy smokers. Methods: One hundred and ninety one healthy smokers, who had undergone a low-dose chest CT (LDCT) scan as part of lung cancer screening and had revisited the health center after a median 23.9 months` time, were recruited into this study. The severity of emphysema was calculated by the direct observation of a radiologist and a pulmonologist indipendently. Longitudinal changes in lung function according to emphysema based on LDCT and type of smoker was analyzed. Results: Of the participants in this study, 25% of healthy smokers had emphysema, which was mild in severity, in older patients (p=0.003) and in heavy smokers (p＜0.001). FEV1/FVC and FEF25-75% were decreased in current smokers with emphysema (p=0.001 and p=0.009, respectively) and without emphysema (p=0.001 and p=0.042). Although lung function was not decreased in ex-smokers without emphysema, FEV1/FVC and FEF25-75% were decreased in ex-smoker with emphysema (p=0.020 and p=0.010). Conclusion: Upon examination with LDCT, the prevalence of emphysema was higher in healthy smokers was than in non-smokers. Lung function was diminished in smokers with emphysema, in spite of former smoker.