제1기 비소세포폐암에서 APT1 발현의 임상적 의미

• Published in: Tuberculosis and respiratory diseases Vol. 68; no. 4; pp. 212 - 217
• Main Authors: 신정아, Jung Ar Shin, 이창률, Chang Ryul Lee, 변민광, Min Kwang Byun, 장윤수, Yoon Soo Chang, 김세규, Se Kyu Kim, 장준, Joon Chang, 안철민, Chul Min Ahn, 김형중, Hyung Jung Kim
• Format: Journal Article
• Language: Korean
• Published: 대한결핵 및 호흡기학회 30.04.2010; 대한결핵및호흡기학회
• Subjects: Acyl protein thioesterase; Biological Markers; Carcinoma; Non-Small-Cell Lung; 내과학; Carcinoma, Non-Small-Cell Lung; Biological Markers; Acyl protein thioesterase
• ISSN: 1738-3536; 2005-6184

Background: Acyl protein thioesterase-1 (APT1) is a cytosolic protein that may function in the depalmitoylation of numerous proteins, including the Ras family. However, the clinical role of depalmitoyl thioesterase in human cancer is not known. We evaluated the APT1 expression in lung cancer tissue and its clinicopathological findings according APT1 expression pattern. Methods: APT1 expression was examined by immunohistochemistry in the tumor tissue from 79 patients, who had undergone curative surgical removal of the primary lesion; all patients had been diagnosed with stage I non-small cell lung cancer between 1993 and 2004, at Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. Results: The APT1 expression was seen in 50 out of 79 (63.3%) cases. The positive APT1 expression was significantly related with histologic subtype and T stage, but was not influenced by differentiation. The positive APT1 expression was not significantly related to patient age, gender, or smoking history. The median follow-up duration was 10.0 years; the 5-year survival rate was 71.0%. The positive APT1 expression group showed significantly worse overall survival and worse disease-free survival without statistical significance. Conclusion: We conclude that positive APT1 expression in stage I lung cancer after surgery is closely associated with overall survival. To evaluate APT1 as a prognostic marker in lung cancer, comprehensive studies on advanced stage cases are needed.