Raw 264.7 cell에서 차가 버섯 에탄올 추출물이 Cytokine 발현에 미치는 영향

Objectives : This study was conducted to investigate the effects Innotus obliquus on the cytokine expression in Raw 264.7 cells. Methods : In Raw 264.7 cells stimulated with lipopolysaccaride(LPS) to Mimic inflammation, Innotus obliquus ethanol extract inhibited nitric oxide production in a dose-dep...

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Published in大韓本草學會誌 Vol. 20; no. 2; pp. 55 - 60
Main Authors 변부형, Boo Hyeong Byun
Format Journal Article
LanguageKorean
Published 대한본초학회 30.06.2005
Subjects
COX-2
IL-1beta
IL-6
Innotus obliquus
iNOS
Raw 264.7 cells
TNF alpha
한의학
COX-2
TNF-alpha
iNOS
Raw 264
Innotus obliquus
7 cells
IL-1beta
IL-6
Online AccessGet full text
ISSN1229-1765
2288-7199

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Summary:Objectives : This study was conducted to investigate the effects Innotus obliquus on the cytokine expression in Raw 264.7 cells. Methods : In Raw 264.7 cells stimulated with lipopolysaccaride(LPS) to Mimic inflammation, Innotus obliquus ethanol extract inhibited nitric oxide production in a dose-dependent manner and abrogated inducible nitric oxide sythase(iNOS) and cyclooxigenase (COX-2). The levels of cytokines were analyzed by sandwich immuno assays. Results and Conclusions : Results provided evidence that Innotus obliquus inhibited the production of IL-b, and IL-6 in Raw 264.7 cells activated with lipopolysaccharide (LPS). These finding suggested that Innotus obliquus can produce anti-inflammatory effect, which may playa role in adjunctive therapy in Gram-negative bacterial infections.
Bibliography:The Korea Association of Herbology
KISTI1.1003/JNL.JAKO200503036958235
G704-000845.2005.20.2.013
ISSN:1229-1765
2288-7199