곽향 추출물의 염증성세포활성물질 억제효과

• Published in: 大韓本草學會誌 Vol. 23; no. 3; pp. 119 - 125
• Main Authors: 배기상, Gi Sang Bae, 박희제, Hee Je Park, 김도윤, Do Yun Kim, 서상완, Sang Wan Seo, 박경배, Kyung Bae Park, 김병진, Byung Jin Kim, 송제문, Je Moon Song, 이경용, Kyung Yong Lee, 나철, Chul Na, 신병철, Byung Chul Shin, 박성주, Sung Joo Park, 송호준
• Format: Journal Article
• Language: Korean
• Published: 대한본초학회 30.09.2008
• Subjects: inflammation; Lipopolysaccharide; LPS; Teucrium veronicoides; TV; 한의학; lipopolysaccharide (LPS); inflammation; Teucrium veronicoides(TV)
• ISSN: 1229-1765; 2288-7199

Objectives: The purpose of this paper was to investigate the anti-inflammatory effects of extract from Teucrium veronicoides (TV) on the RAW 264.7 cells. Methods: To evaluate of anti-inflammatory of TV, we examined the cytokine productions on lipopolysacchride (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms using Western blot. Furthermore, We examined LPS-induced endotoxin shock. Results: 1. Extract from TV itself does not have any cytotoxic effect. 2. Extract from TV reduced LPS-induced Nitric oxide (NO),interleukin (IL)-1b, IL-6 and IL-10, tumor necrosis factor-a (TNF-a) production in RAW 264.7 cells. 3. TV inhibited the activation of mitogen-activated protein kinases (MAPKs) such as p38, extracelluar signal-regulated kinase (ERK 1/2) and c-Jun NH2-terminal kinase (JNK) and also the degradation of inhibitory kappa B a (Ik-Ba) in the LPS-stimulated RAW 264.7 cells. 3. TV slightly increased the duration of survival after LPS-induced endotoxin shock. Conclusions: TV down-regulated LPS-induced NO and cytokines production, which could provide a clinical basis for anti-inflammatory properties of TV.