캔디다균 감염 마우스 모델에서 병독인자의 비교위험도

• Published in: The journal of the Korean Society for Microbiology Vol. 35; no. 4; pp. 317 - 324
• Main Authors: 김동화, 신운섭, 이경호, 김경훈, 박윤선, 박주영, 고춘명, Kim, Dong-Hwa, Shin, Woon-Seob, Lee, Kyoung-Ho, Kim, Kyung-Hoon, Park, Yoon-Sun, Park, Joo-Young, Koh, Choon-Myung
• Format: Journal Article
• Language: Korean
• Published: 2000
• Subjects: Candida albicans; Virulence factor; Relative risk
• ISSN: 0253-3162; 1225-2344; 1598-2467

Candida albicans is one of the most frequently isolated fungal pathogens in human. Recently, the prevalence of candida infection has markedly increased, partially due to the increase of immunocompromised hosts. Proposed virulence factors of the pathogenic Candida are the ability to form hyphae to adhere to epithelial cell surfaces, and to secrete acid proteinases and phospholipases. We measured the relative cell surface hydrophobicity (CSH) and the ability of proteinase production (PROT), phospholipase production (PLase), adherence to host epithelium (ADH), and hyphal transition (Germ). The relative risk of virulence factors was analyzed by lethality test in murine model of hematogeneously disseminated candidal infection. According to Cox's proportional hazard analysis, the statistically significant virulence factors were PROT, ADH, and CSH. PROT was the highest risk factor of them. To evaluate the applicability for the diagnosis and treatment of Candidiasis, we examined the protective effect of the active and passive immunizations with the materials purified from virulence factors and antibodies to them in Candia-infected mice model. The mean survival times of active and passive immunized groups were slightly longer than those of non-immunized groups.