Adiamycin에 의해 손상된 심근세포에 대한 동과의 영향에 관한 연구
To examine the cardiotoxic effect of adriamycin on cultured rat myocardial cells, cytotoxicity was measured by MTT assay after cultured myocardial cells were grown with various concentrations of adriamycin(ADA) for 48 hours. The protective effect of Benincasae Semen(BS) on ADR-induced cardiotoxicity...
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Published in | 동의생리병리학회지 Vol. 16; no. 6; pp. 1207 - 1210 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | Korean |
Published |
한의병리학회
2002
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Subjects | |
Online Access | Get full text |
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Summary: | To examine the cardiotoxic effect of adriamycin on cultured rat myocardial cells, cytotoxicity was measured by MTT assay after cultured myocardial cells were grown with various concentrations of adriamycin(ADA) for 48 hours. The protective effect of Benincasae Semen(BS) on ADR-induced cardiotoxicity was also examined in these cultures. ADR decreased cell viability of cultured rat myocardial cells remarkably in a dose- and time-dependent manners. In protective effect of BS, it was very effective in blocking ADR-induced cytotoxicity. From these results, it is suggested that ADR shows cardioxicity, and the herba extract, as is very effective in preventing ADR-induced cytotoxicity on cultured rat myocardial cells. |
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Bibliography: | KISTI1.1003/JNL.JAKO200217140945935 |
ISSN: | 1738-7698 2288-2529 2283-2529 |