Adiamycin에 의해 손상된 심근세포에 대한 동과의 영향에 관한 연구

• Published in: 동의생리병리학회지 Vol. 16; no. 6; pp. 1207 - 1210
• Main Authors: 홍기연(Gi Youn Hong), 이영미(Young Mi Lee), 이정헌(Jung Hun Lee), 이강창(Kang Chang Lee), 조혜원(Hae Won Cho), 한경수(Kyung Su Han)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2002
• Subjects: Benincasae Semen; Adriamycin; Cultured myocardial cell
• ISSN: 1738-7698; 2288-2529; 2283-2529

To examine the cardiotoxic effect of adriamycin on cultured rat myocardial cells, cytotoxicity was measured by MTT assay after cultured myocardial cells were grown with various concentrations of adriamycin(ADA) for 48 hours. The protective effect of Benincasae Semen(BS) on ADR-induced cardiotoxicity was also examined in these cultures. ADR decreased cell viability of cultured rat myocardial cells remarkably in a dose- and time-dependent manners. In protective effect of BS, it was very effective in blocking ADR-induced cytotoxicity. From these results, it is suggested that ADR shows cardioxicity, and the herba extract, as is very effective in preventing ADR-induced cytotoxicity on cultured rat myocardial cells.