Remifentanil이 QT dispersion에 미치는 영향

• Published in: Korean journal of anesthesiology Vol. 57; no. 6; pp. 737 - 741
• Main Authors: 이상은, Sang Eun Lee, 김영재, Young Jae Kim, 김영환, Young Hwan Kim, 조광래, Kwang Rae Cho, 이근무, Kun Moo Lee, 이정한, Jeong Han Lee, 이원진, Won Jin Lee, 신치만, Chee Mahn Shin, 임세훈, Se Hun Lim, 최영균, Young Kyun Choe, 정순호, Soon Ho Cheong
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회 30.12.2009
• Subjects: Arrhythmia; Heart conduction system; Remifentanil; 마취과학
• ISSN: 2005-6419; 2005-7563

Background: QT dispersion (QTd) is an indirect measure of the heterogeneity of ventricular repolarization and can be used as a risk factor for complex ventricular arrhythmias. We measured the effect of remifentanil on QTd and heart-rate corrected QT dispersion (QTcd). Methods: Sixty ASA class I and II patients, who were between 20 and 60 years old, and who were scheduled for general anesthesia, were studied. After the patient entered the operating room, a 12 lead EKG recording was taken and intravenous infusion of remifentanil was started. The infusion rate was 0.1 μg/kg/min in group 1 and 0.2 μg/kg/min in group 2. Another EKG recording was taken 10 minutes after infusion had started. Results: In both groups, QTd following remifentanil infusion was not significantly different than control values (76.6±23.3 ms vs 81.8±34.9 ms, P=0.459 in group 1; 70.7 ms±29.7 ms vs 73.7 ms±37.1 ms, P=0.734 in group 2). Neither was QTcd: (83.2 ms±25.2 ms vs 89.6 ms±36.2 ms, P=0.371 in group 1; 81.0 ms±35.2 ms vs 83.4 ms±40.9 ms, P=0.829 in group 2). Conclusions: Remifentanil infusion at a rate less than 0.2 μg/kg/min does not change QTd or QTcd. (Korean J Anesthesiol 2009; 57: 737∼41)