ALDH2 유전자형에 따라 나이, 성별로 나누어 비교한 혈중 아세트알데히드 농도에 관한 연구

• Published in: Journal of the Korean Society of Biological Psychiatry Vol. 31; no. 1; pp. 1 - 6
• Main Authors: 주병욱, 정지운, 최세라, 이정석, 허성영, 김현경, 김성곤, Byung-Uk Joo, Ji-Woon Jeong, Se Ra Choi, Jung Seok Lee, Sung Young Huh, Hyeon-Kyeong Kim, Sung-Gon Kim
• Format: Journal Article
• Language: Korean
• Published: 대한생물정신의학회 01.04.2024
• Subjects: 정신과학; ALDH2
• ISSN: 1225-8709; 1225-8709
• DOI: 10.22857/kjbp.2024.31.1.001

Objectives Alcohol is metabolized to acetaldehyde by alcohol dehydrogenase enzyme in the liver and then acetaldehyde is metabolized to acetone by aldehyde dehydrogenase (ALDH) in the liver. There are two main ALDH enzymes which metabolize the acetaldehyde produced during ethanol oxidation. In particular, in the presence of the ALDH2 1*2 allele, the activity of the ALDH 2 enzyme is lowered. As a result, acetaldehyde metabolism is slowed down and acetaldehyde accumulates in the body compared to the ALDH2 1*1 allele. There are many studies that have investigated the blood acetaldehyde concentration according to the ALDH2 genotype, but there are few studies to compare this with age. So we investigated the blood acetaldehyde concentration according to ALDH2 genotype, age and gender. Methods According to the ALDH2 genotype, we divided the group by gender and age. We divided the age group in to three groups which ranged from 20 to 34 years old, from 35 to 49 years old, and lastly from 50 to 64 years old. And then we collected blood samples after 15 min, 30 min, 1 hr, 2 hr, 3 hr, 4 hr, 5 hr and 15 hr of after drinking to measure the blood acetaldehyde concentration. Results In ALDH2 1*2 allele group, there are significant differences of the blood acetaldehyde concentration between the age groups. In ALDH2 1*2 allele and male group, there are significant differences of the blood acetaldehyde concentration between the age groups. Conclusions There are significant differences of the blood acetaldehyde concentration between the age groups according to ALDH2 genotype. Also, there are significant differences of the blood acetaldehyde concentration between the age groups with male gender and ALDH2 1*2 allele. Studies about other factors that may influence the blood acetaldehyde concentration are needed.