Reuterin 및 이의 구조적 특징과 생물학적 활성에 대한 고찰

• Published in: Yaghag-hoi-ji Vol. 66; no. 4; pp. 169 - 174
• Main Authors: 정유라(Yu Ra Jeong), 김예은(Ye Eun Kim), 이상협(Sang Hyup Lee)
• Format: Journal Article
• Language: Korean
• Published: The Pharmaceutical Society Of Korea 30.08.2022; 대한약학회
• Subjects: 약학; Antimicrobial; Disinfectant; Reuterin; Antibacterial; 3-Hydroxypropionaldehyde
• ISSN: 0377-9556; 2383-9457
• DOI: 10.17480/psk.2022.66.4.169

Reuterin, one of the low-molecular organic compounds, contains an aldehyde and alcohol group with threecarbons. It also possesses a certain degree of complexity in chemical structure because of the presence of aldehyde group. In an aqueous solution of reuterin, monomeric, hydrate, and dimeric forms coexist in equilibrium. Reuterin has diversebiological activities, including antibacterial, anticancer, antiinflammatory, and antifungal activities. Specifically, it displaysstronger antibacterial activities and lower toxicities than the existing antimicrobial agents such as glutaraldehyde. Due tothe beneficial biological attributes, reuterin can be a potential candidate for novel functional compounds in the food andpharmaceutical industry. Preparation methods for reuterin include biochemical conversion and chemical synthesis. Biochemical conversion approach employs bioconversion using glycerol and Lactobacillus reuteri and chemical synthesisutilizes acrolein or 1,2,4-butanetriol as a starting material. However, despite its exceptional biological activities, themechanism of action is obscure. Collectively, reuterin has substantial potential as a functional compound in food andpharmaceutical domain. KCI Citation Count: 0