Controlled Release of Epidermal Growth Factor (EGF) from EGF-loaded Polymeric Nanoparticles Composed of Polystyrene as Core and Poly(methacrylic acid) as Corona in vitro

Polymeric nanoparticles composed of polystyrene (PS) as core and poly(methacrylic acid) (PMA) as corona were prepared by the dispersion copolymerization. The potential of the nanoparticles as carriers for recombinant human epidermal growth factor (EGF) was investigated. The nanoparticles showed mono...

Full description

Saved in:
Bibliographic Details
Published inArchives of pharmacal research Vol. 26; no. 8; pp. 649 - 652
Main Authors Park, In-Kyu, Seo, Seog-Jin, Akashi, Mitsuru, Akaike, Toshihiro, Cho, Chong-Su
Format Journal Article
LanguageKorean
Published 대한약학회 01.08.2003
Subjects
약학
Cell proliferation
Polymeric nanoparticles
Recombinant human epidermal growth factor
A431 cells
Online AccessGet full text

Cover

More Information
Summary:Polymeric nanoparticles composed of polystyrene (PS) as core and poly(methacrylic acid) (PMA) as corona were prepared by the dispersion copolymerization. The potential of the nanoparticles as carriers for recombinant human epidermal growth factor (EGF) was investigated. The nanoparticles showed monodispersity and good water-dispersibility. The loading content of EGF to the nanoparticles was very high due to electrostatic interaction between EGF and nanoparticles. EGF was released as a pseudo-zero order pattern after initial burst effect. The nanoparticles were sufficient for A431 cells proliferation.
Bibliography:KISTI1.1003/JNL.JAKO200311922264551
G704-000010.2003.26.8.009
ISSN:0253-6269
1976-3786