ICR 마우스를 이용한 전호의 단회경구투여 독성 실험

• Published in: 대한한방내과학회지 Vol. 39; no. 4; pp. 676 - 685
• Main Authors: 권다혜, 김민영, 황보현, 지선영, 박철, 최영현, 홍수현, Kwon, Da-hye, Kim, Min-young, Hwangbo, Hyun, Ji, Seon-yeong, Park, Cheol, Choi, Yung-hyun, Hong, Su-hyun
• Format: Journal Article
• Language: Korean
• Published: 대한한방내과학회 01.09.2018
• Subjects: 한의학; Peucedani Radix; 50% lethal dose; ICR mouse; single dose toxicity test
• ISSN: 1226-9174

Objectives: The aim of this study was to estimate the single oral toxicity of Peucedani Radix (PR) ethanol extracts. PR is one of the important herbs for removal of phlegm, the viscous turbid pathological product that can accumulate in the body and cause a variety of diseases. However, research on the pharmacologic toxicity of PR is lacking. Methods: In this study, PR was orally administered to 5-week-old male ICR mice at an oral dose of 2,000, 3,000, or 5,000 mg/kg. After a single-dose administration, the mortality and behavioral changes were observed daily and body weights were measured every two days. After 14 days, the organ weight, organ index, macroscopy, hematological analysis, and serum biochemistry analysis were determined. Results: No mortality, body weight changes, abnormal behavioral changes, or anatomical signs of toxicity were found. The organ weight, organ index, hematological analysis, and serum biochemistry analysis were also within the normal ranges. Conclusions: These results suggest that the 50% lethal dose of PR is more than 5,000 mg/kg. This could indicate that PR is a safe drug without acute toxicity and side effects.