Effects of Opuntia ficus-indica var. Saboten Stem on Gastric Damages in Rats

• Published in: Archives of pharmacal research Vol. 25; no. 1; pp. 67 - 70
• Main Authors: Lee, Eun-Bang, Hyun, Jin-Ee, Li, Da-Wei, Moon, Yung-In
• Format: Journal Article
• Language: Korean
• Published: 대한약학회 01.02.2002
• Subjects: 약학; Opuntia ficus-indica stem; Cactaceae; Antigastric lesion
• ISSN: 0253-6269; 1976-3786

The effects of the dried stem powder of Opuntia ficus-indica var. saboten (OF-s) were investigated on gastric lesion and ulcer models in rats. It showed significant inhibition in HCl·ethanolinduced gastric lesion at the doses of 200 and 600 mg/kg p.o. and in HCl·aspirin-induced gastric lesion at 600 mg/kg p.o. OF-s also showed significant inhibition in indomethacin-induced gastric lesion at the doses of 200 and 600 mg/kg, p.o. However, it did not affect both the aspirin-induced and Shay ulcers in rats. It also did not affect gastric juice secretion, acid output and pH. These data indicate that OF-s only possesses pronounced inhibitory action on gastric lesion without antiulcer activity in rats.