쇼그렌 및 비쇼그렌증후군 환자에서 안구표면염색점수와 혈중 비타민 D 농도의 상관관계 비교

• Published in: 검안 및 콘택트렌즈 학회지, 20(1) pp. 32 - 38
• Main Authors: 공예슬, 강규동, 김현승, 황형빈
• Format: Journal Article
• Language: Korean
• Published: 대한검안학회 30.03.2021
• Subjects: 안과학
• ISSN: 2384-0919; 2384-0927

Purpose: To analyze the correlation between the ocular surface staining score (OSS) and serum vitamin D level for patients of Sjögren's syndrome (group A) and non-Sjögren's syndrome (group B) with dry eye symptoms. Methods: In this observational cross-sectional study, The Schirmer I test, OSS, tear film break-up time and serum vitamin D level were measured in 65 eyes of 65 adults complaining of dry eye. Among 65 people, 35 people in group A and 30 people in group B. The Student’s t-test was used for analyzing the ocular surface staining respectively, in group A and group B patients. Pearson’s correlation was used to analyze the correlations of OSS with serum vitamin D level. Results: The serum vitamin D level (rho = -0.245, p = 0.049) was negatively correlated with OSSs. Especially, the serum vitamin D level (rho = -0.440, p = 0.008) was significantly negatively correlated with OSSs in Sjögren's syndrome patients even more than total patient group. Conclusions: This suggests that the OSS is highly related to immunological factors such as vitamin D in dry eyes due to an underlying immunological disease. Finding the exact relationship between the inducer of dry eye and the degree of dry eye and clarifying the correlation seems to play an important role in the direction of treatment for dry eye. KCI Citation Count: 0